Therapeutische Anwendung der Kernspinresonanz Therapie bei Osteoporose - 2016

Therapeutische Anwendung der Kernspinresonanz bei Osteoporose

W. Kullich1, I. Lukenda2, B. Stritzinger1, J. Overbeck2,3, D. Krpan2; 1Ludwig Boltzmann Cluster für Rheumatologie, Balneologie und Rehabilitation, Ludwig Boltzmann Department für Rehabilitation, Saalfelden, Österreich; 2Policlinica K-Centar, Zagreb, Kroatien; 3Facharzt für Orthopädie und Unfallchirurgie, Deggendorf, Deutschland Berichte der nat.-medizinischen Vereinigung Salzburg, Bd. 18, Salzburg, 2016, S. 7–17

Ziel

[...] Untersuchung der Langzeiteffekte der therapeutischen Anwendung der Kernspinresonanz (KSRT) auf Parameter der Knochendichte bei Patienten mit Osteoporose.

Ergebnisse
[...] Die Knochendichte und die Serumspiegel von Osteocalcin erhöhten sich statistisch signifikant von Baseline bis zu 12 Monaten. ß-CTX blieb unverändert stabil.

 

Schlussfolgerung
[...] Eine therapeutische Anwendung der Kernspinresonanz erhöht innerhalb eines Jahres nach einer Behandlungsserie (10 x 1h) die Parameter der Knochendichte. Daher kann die KSRT als Alternative oder zusätzliche Therapie zu einer medikamentösen Therapie bei Osteoporose-Patienten empfohlen werden. 

 

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Non-Pharmacological Treatment of Osteoporosis with NMR-Therapy - 2015

Non-pharmacological treatment of osteoporosis with Nuclear Magnetic Resonance Therapy (NMR-Therapy)

D. Krpan1, B. Stritzinger2, I. Lukenda1, J. Overbeck1,3, W. Kullich2; 1Policlinica K-Centar, Zagreb, Kroatien; 2Ludwig Boltzmann Cluster für Rheumatologie, Balneologie und Rehabilitation, Ludwig Boltzmann Department für Rehabilitation, Saalfelden, Österreich; 3Facharzt für Orthopädie und Unfallchirurgie, Deggendorf, Deutschland Periodicum Biologorum, Vol. 117, No. 1, S. 161–165

Ziel

[...] To demonstrate the long-term effects of the therapeutic use of nuclear magnetic resonance (NMR) on bone mineral density (BMD) parameters in patients with osteoporosis

Ergebnisse
[...] BMD and serum levels of osteocalcin increased significantly from baseline to 12 months. b-CTX remained stable

Schlussfolgerung
[...] Under therapeutically use of NMR-Therapy, BMD-parameters increased during 12 months after a treatment block (10 x 1h). Therefore, NMR-Therapy can be considered a useful alternative or supplement to medical therapy in patients with osteoporosis.


Decrease in extracellular Collagen Crosslinking in Skin Fibroblasts

Decrease in extracellular collagen crosslinking after NMR magnetic field application in skin fibroblasts

I. Digel, E. Kurulgan, Pt. Linder, P. Kayser, D. Porst, G. J. Braem, K. Zerlin, G. M. Artmann, A. Temiz Artmann, Fachhochschule Aachen, Campus Juelich, Kompetenzplattform Bioengineering; veröffentlicht in: Journal of the International Federation for Medical and Biological Engineering, Nr. 1, January 2007, 45:91-97. Sprache: Englisch

Ziel

[...] Our study was designed to evaluate physiological effect of electromagnetic field at nuclear magnetic resonance conditions (NMR) on human skin fibro­ blasts in culture. The aim of the study was to evaluate NMR exposure effects on ECM component changes (mainly collagen), the level of hydration and the cross­ linking level of ECM macromolecules. Furthermore, to investigate the possible NMR influence on proteomic profiles of in-vitro cultured fibroblasts.

 

Ergebnisse
[...] Specifically, for soluble ECM collagens, a noticeable increase in collagen content was detected after NMR application. Quite characteristic changes in 20 protein patterns were detected. They indicate specific alterations in the cellular proteome after NMR application.

 

Schlussfolgerung
[...]
In our study, it was found that NMR exposure induces in fibroblasts distinct changes both in cellular and ECM components. In our experiments, as a response of the cell construct on both static field and NMR exposure, collagen in ECM has turned more soluble (less cross-linked). This induced re-distribution of collagen between solu­ ble and insoluble fractions was observed for all collagen types. Nevertheless, the particular physiological impact of NMR application on fibroblasts proteome is still to be studied on the base of the analysis of the involved signalling pathways and extensive expression profiling.